Sandhya Mukherjee was born on 4th of October 1931 in Calcutta, India. After her matriculation she started learning classical music under Shri Santosh Basu. Later on she took her training under Shri Gemini Ganguly, Prof. A Kannan and Prof. Chinmaya Lahiri. In 1950 she became a disciple of Ustad Bade Ghulam Ali Khan followed by his son Ustad Munavvar Ali Khan.
R C Boral, the music director of New Theaters gave her a song "Ha Ha Ha Hans Ke Jiye Ja" in a film called "Anjaan Garh". She later sang "Ashkon Me Chhipi Mohabbat Ki Kahani" in Pehla Aadmi, which gave her immense popularity in Calcutta. Then she moved to Bombay where she earned fame with a duet with Hemant Kumar "Aa Gupchup Gupchup Pyar Karen" in Sazaa. Later, she sang for Anil Biswas in "Taraana" a duet with Lata "Bol Papiha Bol Re" which was an instant hit. She got films like Ratnadeep, Husn Ka Chor, Fareb etc, but she could not sing for a long time because of her training in classical, her voice was best suited for that.
Her voice had the same Bengali touch as that of Geeta Dutt. In 1966, she married poet Shyamal Gupta and settled with her husband in Calcutta.
She rendered her voice for the following songs:
1. Anjaan Garh | R C Boral |1948|
1. Ab Nahi Dharat Dheer Dheer..
2. Sabya Sachi | Robin Chatterji
|1948|
1. Aayee Mere Jeevan Ki Saanjh Suhani..
2. Dil Bhi Udaas Udaas Chaman Bhi Udaas..
3. Pehla Aadmi | R C Boral
|1950|
1. Taaron Ki Roshni Me Duniya Nai..(with Apresh Lahiri)
2. Ham Chale Nai Duniya Basaane..(with Apresh Lahiri)
3. Ashkon Me Chhipi Mohabbat Ki Kahani..
4. Kaun Kehta Hai Tasveer Tumhari..
4. Sazaa | S D Burman
|1951|
1. Aa Gupchup Gupchup Pyar Karen..(with Hemant Kumar)
2. Ye Baat Koi Samjhaye Re..
5. Taraana | Anil Biswas
|1951|
1. Bol Papihe Bol Kaun Hai Tera Chitchor..(with Lata Mangeshkar)
6. Izzat | Bulo C Rani
|1952|
1. Ishq Me Ho Jao Barbaad..(with G M Durrani)
2. Kya Kya Sitam Sahe Hain Do Din Ki Zindagi Me..
3. Tera Jhoomta Shabaab Jaise..(with G M Durrani)
7. Baaghi | Madan Mohan |1953|
1. Jungle Mangal..
8. Ek Do Teen | Vinod
|1953|
1. Aa Jaa Re Balam Tujhe Meri Kasam..
9
. Fareb | Anil Biswas |1953|
1. Udaasiyon Me Nazar Kho Gai..
10.Husn Ka Chor | Bulo C Rani |1953|
1. Dheere Dheere Dil Me Samaa..(with S D gupta)
2. Dil Lagaane Wale Apne Se Hazaaron Hain..(with Mohd. Rafi)
3. O Jaane Waale Kisi Ka Salaam Leta Jaa..
4. O Sangdil Zamaane Mujkhe Kyun Rulaata Hai..
11. Manohar | S Venkat Raman
|1954|
1. Aayee Basant Ritu Aayee Bahaar Leke..
2. Doob Gaye Sab Aas Ke Taare..
3. Rut Hai Suhaani Raat Jawan Hai..(with Hemant Kumar)
4. Sukh Bhari Duniya Meri Barbaad Jo..
12. Jaagte Raho | Salil Choudhary
|1956|
1. Maine Jo Lee Angrayee Teri Mehfil..
13. Mamta | Roshan
|1966|
1. Tose Naina Laage Re Saanwariya..
14. Chimni Ka Dhuwan | Robin Chatterji
|1973|
1. Beet Jayegi Umariya Ya Fir Na Milegi..